Friday, September 4, 2020
The Impact of Direct Digital Manufacturing on Supply Chains Essay
The Impact of Direct Digital Manufacturing on Supply Chains - Essay Example Eyebrows are getting raised over the capability of DDM in cutting the interest for coordinations administrations, as items would be made at the spot of interest or use. Impact of DDM would be felt in all industry divisions for meeting dire item needs, giving tweaked items and parts of items, which were prior provided in mass through the coordinations business. The vital inquiry before the coordinations organizations overall is whether DDM would influence the matter of coordinations industry for moving products starting with one area then onto the next. Normally future repercussions of the development in innovation can't be denied. When tweaked parts could be gotten to from the neighborhood DDM in a financially savvy and quicker way, who might want to arrange it through a coordinations procedure? Plausibility of getting parts provided locally turns out to be progressively obvious for actualizing changes in the plans of items. As a matter of fact, the hazard to coordinations business i s certified in light of the fact that no organization might want to pay airfreight for getting a section from abroad when it very well may be created locally yet the matter of DDM relies upon advancement in ideas; just virtuoso isn't sufficient. On the off chance that a thought is adequate, it will require some serious energy in proto-composing. 3D printing likewise expects time to process an idea into an item. It would begin a war-like condition for protecting licensed innovation. Imitators and trailblazers, both would make endeavors to introduce their items quick to the market (ââ¬Å"3D Printingâ⬠standard. 27). For getting serious edge from the given situation, just those organizations would get the influence that would design a drawn out promoting technique without considering the benefit factor. Conveyance of items would request exactness of timing in taking the items to the client areas (ââ¬Å"3D Printingâ⬠standard. 30). A gander at the business development of DDM can help in assessing the capability of new innovation clearing the stakes of gracefully chains. Seeing the most recent market patterns on assembling strong items by 3Dprinters, business in added substance fabricating came to $1.2 billion out of 2008 and the chance is that it could twofold in size by 2015. For understanding the effect of DDM business on coordinations, some essential information investigation is obligatory, for example, 75% of the offer of 3D printers has been enlisted for creating regular kind of items while the fair offer of the 3D printers has been made for delivering mechanical items. With the moving toward time, there would be increment in the offer of modest 3D printers, which can be to the tune of 90% market as value deteriorates and usefulness improves of 3D printers. Request of the DDM machine is expanding for model-production and fast prototyping, however for a wide range of machines for delivering completed items too (ââ¬Å"A manufacturing plant on your deskâ⬠standard. 4). The main distinction between the mechanical transformation of the 1800s and the appearing upset of things to come is that the assembling business wonââ¬â¢t have the option to get the advantage of economies of scale that accompanies mass creation. Another distinction would be found in the dissemination of capital, work, and protected innovation, subsequently, in a roundabout way influencing the coordinations business as any effect on different enterprises would get reflected in coordinations, influencing its business potential (ââ¬Å"Print me a Stradavariusâ⬠standard. 9). Examine the example of overcoming adversity of a U.S. organization. Seeing the current status of quick assembling (RM) in the matter of making imperceptible dental supports, U.S. based Invisalign
Tuesday, August 25, 2020
A right of privacy in Australi essays
A privilege of security in Australi expositions Megan Richardsons article primarily centers around the legitimacy of a protection right and whether an Australian right of security has developed. In any case, there are three vulnerabilities that relate to protection: ÃË How will a security right be ensured? ÃË Will the advantages of a security right be shared among business substances? ÃË Is there a connection among protection and the right to speak freely of discourse? The law of certainty can satisfactorily ensure security rights however there has been a few cases that appear to fortify the legitimacy of such a privilege and this has frequent the courts constantly over numerous years. Be that as it may, the assurance of protection interests has as of late been clarified and analyzed in more prominent detail because of the European Convention on Human Rights. On account of Douglas Vs Hello! Ltd, the option to be not to mention was raised as the center of a security right dependent on a general thought of individual self-sufficiency. The case fills in as a milestone case to open the conduits for the advancement of a privilege to protection in the Australian law. In the light of recognizing individual self-governance as the premise of any protection right, it is crucial to decide why individual independence is significant. There are two philosophical clarifications raised in the article, to be specific the Kantian thought and John Stuart Mills thought. The Kantian contention is clear and solid. Individuals are finishes in themselves since they have a reasonable will and this will show itself in choices and activities and the regard because of the individual requires self-governance. John Stuart Mills thought is increasingly utilitarian. He feels that once individuals accomplish a specific degree of government assistance and training, they prosper in a domain where free decision is conceivable. The significance of an individual to have his own wants will create positive changes. Both of these contentions are totally unique however similarly significant in the turn of events ... <!
Saturday, August 22, 2020
Management Of Chronic Arthritis Pain In The Elderly â⬠Free Samples
Question: Talk about the Management Of Chronic Arthritis Pain In The Elderly. Answer: Presentation The task is the commented on book index relating to the interminable wellbeing condition. The point of the clarified book reference is to build up the basic investigation and the arrangement centered abilities. The commented on book index depends on the basic assessment of the proof based writing. With the end goal of the task, an incessant wellbeing condition is chosen and a clinical practice issue identified with constant consideration nursing. The task manages the joint inflammation in the matured consideration setting. The issue with the constant consideration nursing chose is the torment the board. So as to control the writing audit an examination question is created. For explained list of sources the finished hunt procedure is nitty gritty. The commented on list of sources comprises of outline and basic conversation. The book index comprises of atleast 5 academic sources. It is trailed by the combination of the considerable number of articles audited. Interminable wellbeing condition An interminable sickness is the drawn out condition that has no total fix and is related with a few comorbidities. One of the ceaseless wellbeing conditions that will be talked about in the paper is joint inflammation in the matured consideration setting. Rheumatoid joint pain, gout and osteoarthritis are the basic issue looked by the older patients. Joint inflammation is the ceaseless infection that assaults ladies, men and youngsters at any age. It harms the body joints causing exceptional agony and distress. The most normally influenced joints are the Knees, lower legs, neck, back, hips, hands, wrists, fingers, lower legs and toes (Walker, 2012). This interminable misshaping illness and related agony can render anybody crippled without appropriate treatment. Patients with this sickness live in vulnerability about the obscure outcomes in future. A few sorts of joint inflammation are hard to analyze. The treatment for joint pain as a rule comprises of agony executioners, calming ailment and hostile to rheumatic medications. Aside from the pharmacological treatment, non-pharmacological treatment incorporates change of way of life and torment the board procedures. A portion of the side effects of the joint inflammation is weakening to such an extent that the patients lose versatility and joints quality. The patients are accordingly compelled to change the way of life to have the option to deal with the exercises of day by day living (Jia Jackson, 2016). Issue identified with interminable consideration nursing The regular test for the medical caretakers thinking about joint inflammation patients is the side effects the executives, for example, agony and flares. Consistently in the crisis room it is awful to see the licenses with joint inflammation. The patients show up in ER with exceptional agony or flares. Moderately aged people are most every now and again experienced in the crisis room. Joint pain and maturing are related with a few comorbidities. It incorporates osteoporosis, cardiovascular illness and malignancies. With the expanding maturing populace the predominance of joint inflammation particularly rheumatoid joint inflammation is assessed to build (van Onna Boonen, 2016). These elements altogether hamper the administration of joint inflammation. Throughout the years there is an expanding worry among the attendants neglecting to deal with torment the board worries of the patients with joint pain. Then again, the old patients also do not have the information required to deal with the side effects, which is a test for medical caretakers. According to the writing, there is deficient treatment of the torment as it will in general be thought little of. In the administration of the patient consideration, the attendants go about as middle person between the patients and the doctors. Medical caretakers assume a fundamental job in outpatient torment the executives. Agony the board is focus in human services today given the narcotic emergency (Fitzcharles, Lussier Shir, 2010). There is an absence of information on factors going about as obstructions for medical attendants to execute compelling agony the executives procedures. The method of reasoning for the picked nursing issue is the experience seen from one of the relative experiencing the joint pain and disappointed with the torment the board procedures. Patients fulfillment with torment control is known to be related with the key commitments of the medical caretakers. In this way, it is important to distinguish a nd comprehend the boundaries of the medical attendants to oversee torment side effects of the joint inflammation patients. Search technique: Research question The exploration question to manage the writing audit as a piece of the proof based medication, which includes building up an inquiry dependent on the issues related to the illness or the patient. Utilizing the exploration question, proof will be recognized. The exploration question for the commented on book reference is- What are the instructive needs and hindrances of the medical attendants thinking about the patients with joint inflammation (gout, rheumatoid joint pain, and osteoarthritis)? 2. The key themes communicated in the examination question are the nursing instruction needs in thinking about joint pain patients. The point likewise communicated is the difficulties confronted/saw by the medical attendants in thinking about the joint pain patients. 3. Search terms The quest terms utilized for separating the examination papers for commented on book reference and narrowing the exploration are- Joint inflammation care, rheumatoid joint inflammation care, gout the board, osteoarthritis, nursing care, joint pain nursing care, torment the executives joint inflammation, nursing instructive requirements for joint pain, nursing obstructions for joint inflammation treatment, supplier hindrances in gout the executives, and patient and supplier instructive needs in osteoarthritis. For compelling examination the Boolean administrators AND, OR and both were utilized. Databases utilized To locate the best accessible writing the electronic databases looked were MEDLINE, Cochrane library, and Google researcher. The Cochrane and MEDLINE database are picked as it is routinely refreshed. The progression utilized for looking through is the imminent associate investigations and afterward descending to the case reports (Rollyson, 2016). The hunt was confined to articles distributed in English language and between 2015-2018. 5. Database looked with watchwords and expressions. An aggregate of 110 articles got The articles were examined for titles, and modified works to decide the significance. It will help wipe out the unessential articles. For additional disposal the full content articles are filtered to decide the significance. 6. The initial 20-30 articles were identified with dementia, knee arthoplasty, matured consideration setting and the difficulties looked by the attendants in these regions. Also there were some more papers on the suggestions for the joint inflammation the board and patients hindrances in joint pain the board. There were a sum of 67 articles and relatively few were pertinent. Along these lines, the pursuit was refined by changing the hunt terms. 7. For exploring the databases the inquiry terms utilized were: rheumatoid joint inflammation AND supplier obstructions, osteoarthritis AND nursing hindrances, gout AND supplier boundaries, medical attendants preparing necessities AND joint inflammation the executives, medical caretakers instructive needs AND caring joint inflammation, medical attendants instructive requirements AND rheumatoid joint pain OR osteoarthritis. These key terms additionally assisted with narrowing down the exploration. The hunt produced 33 applicable articles 8. Similar databases were again utilized for separating the exploration papers utilizing the altered hunt terms. The consideration standards were explore paper distributed between 2012-2018. The patients must be experiencing joint inflammation and incorporates medical attendants and the patients as the exploration members. The investigation directed in Australia just as in other nation is considered for wide point of view. The avoidance models were audit papers, reflection reports and case reports. This further limited the hunt. Utilizing these model 12 articles were rejected. The hunt at that point created 21 articles and in the wake of looking over titles, modified works, and full content 16 articles were rejected. At last five articles were chosen for clarified book index believing it to be generally fitting. Commented on The investigation investigated the patient and suppliers view of the disease, which is gout. The investigation utilized subjective research worldview. After leading the semi organized eye to eye meet with the patients and the medical attendants, it was discovered that the medical caretakers had absence of information about the idea of gout and its suggested administration. The attendants neglected to use the clinical rules for gout. The medical attendants were found to give just imperfect data. It was because of absence of preparing and training of gout related best practice. Another boundary for medical attendants was absence of motivating forces to improve treatment and manifestations the board. In light of the meeting the patients also had misguided judgments concerning the idea of gout. Be that as it may, the discoveries of as far as possible generalisability because of provisos and there is little example size (Green et al., 2015). The quality of the paper is its suggestions wit h improving the guidelines of care and training needs in this condition. The general content is efficient and the examination objective is satisfied. The cross-sectional overview proposed to recognize the instructive needs of medical caretakers thinking about osteoarthritis and rheumatoid joint pain. The medical attendants respondents were found with less trust in their abilities and information when thinking about osteoarthritis patients. The strategy for examination was suitable thinking about the exploration objective. The attendants were uncouth in torment medicine for the patients, exhorting patients on practices and uncertain about the manifestations the board when thinking about the rheumatoid joint pain quiet. The investigation infers for future preparing that must contain key parts like drug and joint security. The examination depends on satisfactory foundation explore and the contentions are very much bolstered with the pertinent sources. The outcomes are all around clarified with graphical representations and content is efficient. The review nonetheless, had confinements like little example size and the enrollment looks like that the experts were at that point familiar with the medical caretakers. The qualities of the non react
Comparing 2 Cities Free Essays
Bangkok and Seoul are notable urban communities of Asia. Bangkok is the capital primary business focus of Thailand and Seoul is the capital principle business focal point of South Korea. While they are diverse from various perspectives, they likewise have a few likenesses. We will compose a custom paper test on Looking at 2 Cities or on the other hand any comparative subject just for you Request Now This report will investigate a portion of the monetary, history, physical, populace highlights of the two capitals. There are a few similitudes between the two urban communities. Right off the bat, the two urban areas center around produced business. Furthermore, the money and exchange are the significant enterprises of their economy. Thirdly, them two have long chronicles. Seoul, is indeed, the more established of the two urban areas. Seoul was established in 1394 while Bangkok was established in 1782. Conversely, the two urban communities have some huge contrasts in physical highlights. Right off the bat, Bangkok is a lot greater than Seoul, involving 1562 sq kms. Then again, Seoul is genuinely little city, being just 627 sq kms. Furthermore, the areas of Bangkok and Seoul is extraordinary. Bangkok, which is in focal Thailand , is situated on the banks of Chao Phraya River. It is around 22 kms from the riverââ¬â¢s mouth. Be that as it may, Seoul is situated on banks of the Han River in north-western South Korea, about 3kms from the Port of Inchon. At long last, the number of inhabitants in the urban areas vary enormously in size and there is a significant distinction in their structure. Right off the bat, Seoul has a little more than ten million individuals though Bangkok has just 7. 5 million individuals. Furthermore, most of the individuals in Bangkok is Thai with 75 percent and 25 percent individuals go to another nations including Chinese, Indian, Burmese, Khmer and Vietnamese. Then again, the fundamental structure of individuals in Seoul is practically all Korean. Step by step instructions to refer to Comparing 2 Cities, Papers
Friday, August 21, 2020
Micro-Finance in Bangladesh Essay Example | Topics and Well Written Essays - 500 words - 12
Miniaturized scale Finance in Bangladesh - Essay Example Venture administration comprises of various exercises, for example, those identified with corporate dynamic and hierarchical structures. à Bangladesh is delegated a Least Developed Country by the United Nations Organization. With a populace of around 125 million, for example more than double the number of inhabitants in Britain, itââ¬â¢s ailing in pretty much every possible asset for human utilization. The Grameen Bank has started a lodging advance plan among others for the less fortunate fragments of Bangladeshis with the goal that they would acquire regardless of whether they can't show insurance. Those asphalt tenants and vagrants on government properties have halfway profited by this plan. They are the main gathering of outer partners, while those contractual workers are additionally considered as outside partners of the undertaking. Be that as it may, representatives and directors on destinations are viewed as inner partners (Cadle and Yeates, 2007). The administration of Bangladesh and the universal network, for example, INGOs, the World Bank, the UNICEF and the IMF are likewise associated with these activit ies as suppliers of assistant administrations, for example, safe drinking water, schools, emergency clinics, etc. The accompanying partner map shows how different partners of a comparable undertaking would be brought under a solitary guide for the examination of connections inside and without the venture. While the physical element of the venture may be constrained to its essential lodging venture, its genuine effect would be felt a long ways past the most distant corners of the nation itself. à While this sheet doesn't give a nitty gritty administration structure to each partner bunch engaged with the task, it satisfactorily delineates how each significant partner bunch is overseen through the undertaking administration process (Carroll, 2006). Partners may have various degrees of enthusiasm for a venture contingent upon the degree of effect on them.
Thursday, August 6, 2020
Congratulations! You got the job.
Congratulations! You got the job. *Sigh* So I went and wrote this whole entry about women in engineering that was based off of my initial comment that Ive never experienced anyone directly saying that women were inferior to men and immediately got a comment stating just that. Are you guys just out to get me or what? =P So Momchil, here are my thoughts, short sweet, and to the point: Everything you just said is wrong. People are just people. The end. And now Im done with all of this deep discussion about admissions and learning from rejection and sexism. I am just plain moving on people. Here we go. This week has been simultaneously awesome and horrendous. You know what I mean, right? I dont think Im going crazy. On Monday I had my first shift on the MIT Ambulance. EMTs must protect patient privacy, so were never allowed to discuss calls weve been on. That wont be hard- there werent any. I guess that means that MIT studnts are healthy, right? Anyway, I still learned a lot. Every crew is responsible for doing a checklist and making sure the ambulance is fully stocked, so I did the super long one to learn where everything was. The crew chief and second were really cool- they knew it was my first shift, and they were really patient and took a lot of time to show me things. (Each crew must have at least 2 people- a crew chief who has a lot of experience and runs the calls, and a second rider who must be an EMT but can have almost any level of experience. Optionally, there can be a third rider who only needs CPR certification. Third riders are there to learn and observe and basically be bossed around by the other crew members. =) Newly certified EMTs remain thirds until they get enough experience to work as second riders.) After a lot of exploring the ambulance, they let me play with the stretcher. (Mostly I just think Mike, the second, wanted to sit in it and be wheeled around and pulled in and out of the ambulance.) After that, we got to sit around in the (really awesome) bunk room for about 5 hours. I got a lot of HASS reading done. =) Then, I found out that I got a new job! Ready for it? You sure? Its nerdy. Im the newest member of the IST (Information Services and Technology) Computing Help Desk. This basically means that I will be the person on the other end of the line when you call tech support in 6 months. After I got the job, we realized that the field hockey season would interfere with mandatory training meetings. We were basically worried that the summer break followed by my abscence from training meetings would let me forget everything I learned this spring. The timing was just no good. So the new plan is this: Im going to go in and observe students working there. Then next semester, if I think that Im still interested in the job, I might just get thrown in with the next cycle of hires who will start working in October. A little weird, but in the end a pretty cool solution to the problem. So I have a job. Stay tuned, in 6 months I might tell you about my first day. =) The middle of the week you know what? Im just not even going to go there. I dont even want to think about it. I, like everyone, was really, really anxious for spring break to arrive. And now its here. How wonderful. Then today, I passed my written exam, which means Im now a real-life certified EMT. That was pretty cool. I spent my lunch break working on top-secret stuff with the other bloggers. *grin* I announced to the room that Id be attending the Princeton admitted students meeting, and they all gave me the weirdest stares! I was so confused until I finally realized that to me, Princeton is a city, but to the rest of the world, Princeton is a college. So they all thought I was going to a meeting for students who were admitted to Princeton, when what I really meant was that I was going to hang out with the students admitted to MIT who happen to be meeting in Princeton. Sheesh. *eye roll* Admitted student meetings are fun. You should go. Tomorrow Im going to the Boston FIRST Regional. Then Ill finally post the pictures from Manchester in one big FIRST-happy entry. Yay. Read on for responses to comments! Responses to comments: Anonymous said: MIT stinks Laura.It does sucks. Hee. Thats creative. Melodie said: Question: How much do you suggest we go to CPW? Im playing at Carnegie Hall the weekend before, and Im missing 3 days of school because of that, so if I miss 5 straight days, my teachers are liable to send me a low-scholarship =/ I was at one of the summer programs, but my RA said that MIT in the summer is very different from MIT during the school year. CPW rocks. A lot. You should definitely try to come if you can. Ive never been here in the summer so I dont actually know, but I cant imagine that its the same. If you have a lot of questions about MIT and youre still struggling to make a decision, CPW is a great chance to learn a lot about MIT. Of course, the school youre actually in now is pretty important too. =) Just keep in mind that you can come to as much or as little of CPW as you want. Feel free to show up only for the actual weekend days. Im not sure how feasible that is for you (I guess it depends on how far away you live and the travel time involved), but its definitely an option. Mike W said: Hmmmgetting rejected at MIT is tough, especially when things have also taken an incomprehensible turn for the worse in several other activities Ive been dedicated to longer than Ive been dedicated to getting in to MIT. I feel your pain. My senior year involved a lot of things I was really dedicated to falling apart. It was pretty painful. Hang in there, and make the best of it. And good luck with calc! aRdho said: are u real MIT students? :D thats cool.. Haha. Yup, real life MIT students. Hamster said: Over time Ive read several people talking about their HASS classes like they are more enjoyable than their engineering/science courses, which always surprises me because it conflicts with the supergeek MIT stereotype. Is it that you like them because they are easier? If you truly just enjoyed the material more, why wouldnt you major in a humanities subject? Wow, thats a great question. I think there are several answers. For one, its just an MIT students nature to complain. No matter how much he/she loves math and science and engineering, chances are that the average MIT student loves to rattle off a huge list of psets and tests and labs and projects that they have to do. Plus, bonding with each other as MIT technical classes kick your you-know-what is a time-honored tradition. So even if you love physics, after being up to all hours of the night working on a terrifically difficult pset and then getting beaten up by a really hard math examyou just think, Ahh. Simple, enjoyable reading. With conceptual questions. No calculator necessary. *contented sigh* Plus, speaking as a freshman, humanities classes are my only chance to choose my classes. So far this year, Ive taken bio, chem, physics, calc, multivariable calc, and differential equations. I personally love physics but its still just a requirement. On the other hand, I got to pick what ever I wanted from a huge list of humanities classes. But mostly I just think its nice to have a change of scenery. Edmund said: Growing up in NJ was pretty cool def. miss NY style pizza in Maine and good bagels :)) Oh. Oh I know. Pizza and bagels are the two things I miss most about NJ. Uhhyou know, after my family and stuff. Im going home Sunday morning for break and I cant wait to go out to get real pizza. Yum.
Monday, June 22, 2020
Importance of General Course Essay - 275 Words
Importance of General Course (Essay Sample) Content: Importance of general education courseStudent nameInstitutionImportance of general education courseThe general education is very important in the education and learning of the student. These courses not only make the student diverse in knowledge but also help the students appreciate the knowledge in other area of life. For example, a student learning general history is able to appreciate the roles of culture and understand how the modern world is influenced by the historical decisions that were made by the people who lived before us. It will also help the student appreciate the roles that todayà ¢Ã¢â ¬s decision will have in informing and shaping the futureThe general education acts as a tool for enlightening the student on the causes of some things in life and also assist them about the emerging and current issues surrounding them. The student will be able, for example, when they study political and business to understand how these two factors relate in shaping the current decision (Werts, 2014). The studies in psychology will inform the student on the philosophical nature of the human beings behavior and therefore aid the student in understanding certain behaviors in people, why they are behaving the way they are and therefore ease their interactions.In addition the general courses offered in the universities help form a sound and solid base for the students. Usually, the students in their early learning may not have found a bearing on their studies and the general courses aid them in understanding several factors, arouse interests in them and therefore guide them in decision making. These courses also help them later in their studies. Some of the concepts learnt in these general course may apply to their specific courses. For example, some co...
Saturday, May 23, 2020
The Approaches And Practices Of Language Teaching Essay
The Approaches and Practices in Language Teaching Communicative Practices in Language Teaching What is communicative language teaching (CLT)? Brown (2014, p. 236) offered the following four interrelated characteristics as the definitions of CLT: 1. CLT helps students develop the four competences instead of merely focusing on their linguistic competence or grammatical competence 2. CLT enables learners to use the language for meaningful purposes in authentic situations. Learning language forms are not the aim of the approach, but to enable them to engage in authentic interactions 3. Fluency and accuracy activities complement each other as is seen in the underlying communicative techniques. 4. Students are expected to use the language naturally and in unrehearsed contexts Itââ¬â¢s important to engage students in doing some communicative practices. Richard (2006) explained that communicative practices are those activities that focus on exchanging real information and using language in an authentic context, thus the communication is based on the specific situation and not predictable. Communicative language teaching has been proven to be effective in improving studentsââ¬â¢ communicative abilities and other language skills. Richards and Rodgers (2001) also wrote that an important goal of communicative language teaching is to help students improve their communicative competence and other language skills. This indicates that the communicative activities can help language learnersShow MoreRelatedCulture and Foreign Language: Teaching and Learning Essay1488 Words à |à 6 Pagesthis subsection, different approaches to teaching culture within the foreign language teaching practice and different views of the term ââ¬Å"cultureâ⬠are going to b e presented as a mean to explore the close relationship between culture and language and determine what is understood as culture in this study. As it was mentioned above, there are different definitions of culture. These views have relied on the different language acquisition theories and teaching approaches that have emerged in the historyRead MoreThe Exploration Of Grammar Teaching Approaches On Efl Classroom1501 Words à |à 7 PagesThe exploration of grammar teaching approaches on EFL Classroom 1. Introduction Grammar learning is a study about words and the ways words work together is, it is the ruled-governed behavior that forces language users put words together into sentences. No one can use the language without fellow its principles. Therefore, Study grammar is the must once person want express themselves clearer and more efficient, especially when speaking in a academic circumstance or communicating in artistic mannerRead MoreTeaching And Learning English As A Foreign Language774 Words à |à 4 PagesCourse: Advanced Teaching Methodology Name: à ¢n à Class: 2016-B Instructor: à °Ã ¡ng, Ph.D. Taking the course of MA on TESOL, whose design is research-oriented, post-graduates are required to accomplish credit subjects including Advanced Teaching Methodology. It is obviously an opportunity for master students not only to review what they have learned but also to have an in-depth insight of issues related to teaching and learning English as a foreign language. Two-third ofRead MoreThe Pedagogical Aspects Of Communicative Language Teaching984 Words à |à 4 PagesCommunicative Language Teaching This essay will take just a peek at some of the pedagogical aspects of Communicative Language Teaching and the teachers therein. As the U. K. entered the common market (EEC) in the early 1970s. A sharp rise in demand from our new European neighbours for The English Language landed on our shores. Due to the modernization of secondary schools not only in Europe but indeed worldwide, languages were a hot commodity and many were on offer, English being most sort afterRead MoreTeaching English For Speakers Of Other Languages ( Esol )1120 Words à |à 5 PagesThis essay attempts to analyze the effect of different approaches to grammar teaching in the English for Speakers of Other Languages (ESOL) classroom. Basically, two approaches which are task-based learning (TBL) and presentation practice production (PPP) will be discussed and compared from different aspects. A great quantity of English teachers consider the significant part of English teaching is about improving the communicative competence of students and grammar is less concerned than it. ItRead MoreTeaching Phonics And Teach Phonics1474 Words à |à 6 Pagesto teach children to read and write, with this comes different approaches that teachersââ¬â¢ need to be aware of. Phonics is one of the approaches adopted by teachers when teaching children to read and write. Adopting different methods of teaching phonics its what makes teachers effective, and adaptive. This essay aims to look closer at phonics and some of the different approaches used to teach phonics in the classroom. Phonics approaches that will be discussed in this paper include synthetic phonicsRead MoreA Study of Learning Strategies in L2 Acquisition1660 Words à |à 7 PagesA Study of Learning Strategies in L2 Acquisition ã⬠Abstractãâ¬âWith the concept of autonomy being part of the mainstream of research and practice within the field of language education, the study of learning strategies in L2 acquisition has drawn much attention. This paper discusses the issues covering the fundamental aspect: identification and classification of learning strategy. The problems are reviewed concerning the definition and classification of learning strategies and then the paper tentativelyRead MoreSociocultural Approaches And The Construction Of Knowledge1650 Words à |à 7 Pagesââ¬Å"Sociocultural approaches emphasize the interdependence and individual processes in the construction of knowledgeâ⬠.(John-Steiner,V and Mahn,H 1996).The real understanding of constructivism is only paying much attention on the learnersââ¬â¢ previous experience and background knowledge .It maintains that individuals create or construct their own new understandings or knowledge through the interaction of what they alre ady believe and the ideas,events,and activities with which they come into contact.(FacultyRead MoreTeaching Phonics And Teach Phonics1414 Words à |à 6 Pagesteach children to read and write, with this comes different approaches that teachers need to be aware of. Phonics is one of the approaches adopted by teachers when teaching children to read and write. Teachers adopt different methods to teaching phonics its what makes them effective teachers and adaptive. This essay aims to look closer at phonics and some of the different approaches used to teach phonics in the classroom. Phonic approaches that will be discussed in this paper include synthetic phonicsRead MoreEssay On Strengths And Weaknesses Of A Good Teacher1378 Words à |à 6 Pages A good teacher is not defined by a specific personality or style of teaching; rather, a good teacher is defined by her commitment to her students learning. A good teacher is someone who is patient with her students, who creatively and relentl essly finds helpful ways to communicate ideas to students, and who instills confidence in her students by setting them up for success. A good teacher inspires her students to strive for more than they think possible. A good teacher teaches her students how
Monday, May 18, 2020
Tuesday, May 12, 2020
The Effect Of Advertising Weight On Sales Of A Product
1 Summary This report describes in detail the model that has been developed, with the aim to investigate the effect of advertising weight on sales of a product which subsequently reflects the changes on profit of the company. The report also explains the mechanism of the model in addressing the concern of the Marketing Director regarding the feasibility and profitability of increasing sales by 100%. 2 Introduction and General Assumptions 2.1 Experimental Coverage It is assumed in this model that there are only 15 terrestrial broadcast television areas in the whole country and that the experiment covers the entire area of the country. 2.2 Equal Sales Arising from Each Area Sales in standardised units are recalculated to the real sales volume in 2015 (Appendix 1, Column F). To obtain an unbiased and comparable result, total sales in each region are assumed to be equal, hence sales arising from each area in 2014 is à £26,024/15 = à £1,734.93, and this figure will be adjusted according to the percentage change to obtain sales figures in 2015. 2.3 Cost Our model considers only the cost incurred by advertisement and ignores all other costs for calculation purposes. That is, Total profit = Profit contribution of sales - Media cost. 2.4 Allocation of Resources The total of advertising weight of the 15 areas in 2015 is 1500 standardized units, which is the same in 2014 (15 areas x 100 base units = 1500 units), thus suggesting that the total resources spent on advertising is theShow MoreRelatedAdvertising Is Not Ethical?956 Words à |à 4 Pagesmedieval times the use of advertising has been in use whether it was capturing a thief or raising taxes. From industrialization and promoting new cars through advertisement, it has changed the way the whole world operates with the introduction of new and improved items. Today advertising has become a 150 billion dollar industry (ConsumerNation). Advertising is a part of everyday life because it helps companies promote new products, but is is advertising ethical? Advertising is not ethical because itRead MorePropaganda Techniques Today s Advertising By Anne Mcclintock1673 Words à |à 7 PagesIn the essay, ââ¬Å"Propaganda Techniques in Todayââ¬â¢s Advertisingâ⬠by Anne McClintock, McClintoc k shows seven different ways that propaganda is used. One mostly used by advertisement today would be Glittering Generalities, using positive words to bring attraction to their product while concealing the actual meanings. They will use inspiring words that are very vague that the consumer would not really understand what the product would really do to benefit them but would be inspired to buy it anyways. AnotherRead MoreMarketing Analysis : Health Marketing Communications Essay1724 Words à |à 7 Pages In summary, Thai people are becoming more concerns about health including their body weight, which causes the high number of sales growth of alternative healthy foods and supplements in the country. While weight management supplements, has been forecasted to dominate 40% of consumer health products in the year 2020, bringing more opportunities for brands to penetrate into this market segment. However, brands have to carefully consider the credibility of marketing tools when approaching health-consciousRead MoreWeight Loss and Ideal Target Market964 Words à |à 4 Pages1. What makes Metabical different from the other weight-loss products on the market? Medibical is the first FDA-approved prescription drug for the overweight segment (BMI 25-30). It is a low-dose formula that reduces stress on heart and liver functions. Metabical also contains a controlled-release feature that requires only one pill be taken per day which leads to better patient compliance. Participants experience dramatic weight loss with an average 26 pounds for BMI 28-30 and 15 pounds for BMIRead MoreRtd Fruit Drinks-Category Attractiveness Analysis Essay1541 Words à |à 7 PagesC515 RTD Fruit Drinks-Case Analysis 2 Category Attractiveness Analysis Group 4 * Customer needs and behavior * 100% juiced product in bottle form * Plastic bottles-enter vending market segment? * Sugar Free (I donââ¬â¢t know same as diet?) * Snapple + Energy product * Powder form to add to bottled water * Low calorie option (pretty low already 100-120 calories)/low carb * Large carton option in more flavors * Market or market segment sizeRead MoreAdvertising Is Not Ethical?971 Words à |à 4 Pages From the start of the medieval times the use of advertising has been in use, whether it was a way to inform the people, capture a thief or raise taxes. By the industrialization age of promoting new cars through advertisement, advertising has changed the way the whole world operates with the introduction of new and improved items. Today ââ¬Å"United States has become the largest advertising market in the world (Statista). Advertising is a part of everyday life that can target different age groups becauseRead MoreObesity : Obesity And Obesity Essay1740 Words à |à 7 Pagesprediction that all fifty states will have obesity rates above 44% by 2030, with some as high as 66.7% (Hellmich). So what is obesity? Obesity is defined as being about thirty pounds over a healthy weight. The ââ¬Å"healthy weightâ⬠depends on several factors such as age, gender, and height. The extra weight that comes with obesity can cause or increase the risk for several illnesses such as diabetes, heart disease, stroke, cancer, sleep apnea, along with many others. The health care cost of obesity relatedRead MoreThe Negatives Of Fitness Advertising995 Words à |à 4 Pagesunrealistic body images and displaying false results. Fitness advertising can be found in print and broadcast forms. While fitness advertising can be viewed as having both positives and negatives, I believe fitness advertising is negative. This paper will discuss the negatives of fitness advertising, to include creating negative body images and promoting false results. It will, also, address the counterarguments against fitness advertising being negative. Many fitness advertisements proclaim the ideaRead MoreThe Media And Its Effects On Teen And Young Undeveloped Brains1237 Words à |à 5 PagesThe advertising business views teenagers in society as a viable market section, due to their immature understanding of the media and its dazzling impact on teen and young undeveloped brains. The media is progressively specializing in children and adolescents to captivate with advertisements. according to market research corporations, teenagers are vital to marketers because they can pay a considerable open income, spend family cash easily, and they are easily able to influence their families to spendRead MoreEffects Of Advertising On Women s Body1239 Words à |à 5 Pageswomen stated that the images portrayed on television, movies, fashion magazines, and advertising makes them feel insecureâ⬠(Hitz 1). Although certain companies have started campaigns to promote self-confidence within oneââ¬â¢s own skin, society overpowers the mind of women when it comes to how a body should look. Billboards and commercial advertisements about how to lose weight and get fit in a short amount of time effects a person mind; by implying that the way they look is not enough to be considered beautiful
Wednesday, May 6, 2020
Cyber Bullying And Its Effects On Children - 866 Words
The Internet is another media outlet that is abundant with violent content. Studies show that 90% of American teenagers use the Internet which is vastly unregulated (Lenhart). Thus, children have easy access to pornography, websites with cruel and racist content, and real-life scenes of violence. With pornography and profanity just being a Google-search away, free, and mostly without age restrictions, children tend to develop sexual curiosity at a very young age. According to Network World Inc., terms related to ââ¬Å"sex and porn were near the top of the [search] listâ⬠not only for teenagers but even for ââ¬Å"the sevens [year olds] and underâ⬠(Skinner). As a result of unsupervised usage of social networking websites and chat rooms, children frequently become victims of cyber bulling or prey to sex offenders. Bullyingstatistics.org reports that ââ¬Å"over half of adolescents and teens have been bullied onlineâ⬠(Cyber Bullying Statistics). Cyber bullying can have devastating consequences on children. 15 year old Amanda Todd killed herself after she was bullied online by her schoolmates (Wikipedia, Suicide of Amanda Todd). Additionally, internet chat rooms can be a hunting ground for sex offenders who target children online. The online children safety advocacy group PureSight states that ââ¬Å"one in five U.S. teenagers who regularly log on to the Internet says they have received an unwanted sexual solicitationâ⬠(Online Predators ââ¬â Statistics). Using social media websites is one of the mostShow MoreRelatedCyber Bullying And Its Effects On Children1314 Words à |à 6 PagesBullying, according to Oxford Dictionary, is the use of ââ¬Å"superior strength or influence to intimidate, typically to force someone to do what one wants.â⬠Growing up, the only bullying that I have witnessed is on the television. The majority of people perceive a bully as a tough boy threatening another for his lunch money, but times have changed in unison with technology evolving. One of the overwhelmingly popular uses of the internet is to contact friends and relatives by posting pictures and sendingRead MoreCyber Bullying And Its Effects On Children And Adults Alike921 Words à |à 4 Pages Technology has consumed our generation of children and adults alike, such luxuries such as cell phones and internet, have made our ways of communication much more convenient and accessible. Whether it be for pleasure,intimidation, or education our children are interracting more and more via the internet and social media accounts. This new media has created two new problems for students and teachers to deal with, cyber bullying and sexting. The biggest consequence is how to punish them. As peopleRead MoreCyber Bullying And Its Effects On Children And Adults Across The Globe1693 Words à |à 7 PagesIntroduction Bullying doesnââ¬â¢t just happen on the playground or in the workplace; it has now taken over the Internet and popular social media platforms such as Facebook, Twitter and Instagram. The term for online bullying is referred to as ââ¬Å"cyber-bullyingâ⬠. ââ¬Å"Cyber-bullying is defined as the use of email, cell phones, text messages, and Internet sites to threaten, harass, embarrass, or socially excludeâ⬠(Patchin, 2015). Much like the face-to-face bullying some may encounter in school can cause physicalRead MoreCyber Bullying Must Be Improved And Consistent1267 Words à |à 6 Pages Amanda Bridges Ms. Shultz / Mrs. Seymore English 5th Period 28 January 2015 Cyber Bullying Have you ever been cyber bullied? The effects of cyberbullying are greater than many people have come to realize. Cyber bullies have been around for a long time, but technology now gives them a whole new way to get to their victims easier and faster. Cyberbullying is the use of information technology to repeatedly harm or harass other people in a deliberate manner (abouthealth). Cyberbullying happensRead MoreThe Social Problem Of Peer Pressure1659 Words à |à 7 Pagespressured into bullying by their peers and conforming to peer pressure that leads to Cyber-bullying and Cyber-crimes. Bullies are misinterpreted as perpetrators; however, they were at some point victims too and created due to lack of social intervention and significantly affected by the victimization by their peers. Cyberbullying: Through the eyes of children and young people, it acknowledges how bullying has entered a ââ¬Å"digital eraâ⬠and the need for professionals and adults to protect the children by helpingRead MoreEssay about Cyber Bullying1223 Words à |à 5 Pagesbut to those who have been or are currently victims of cyber bullying words can be the difference between life and death. ââ¬Å"Words hurt, and they hurt much more when repeated in the echo chamber of the Internet.â⬠(Rep. Linda Sanchez via FoxNews.com) There are at least 4 examples in the United States where cyber-bullying has been linked to the suicide of a teenager [1]. What is Cyber Bullying? Cyber bullying is defined as ââ¬Å"bullying through information and communication technologies, mediumsRead MoreCyber Bullying And Its Effect On Society1536 Words à |à 7 PagesBullying has been an extreme issue all around the world for hundreds of years, and since modern technology has advanced, so has cyber bullying. ââ¬Å"ââ¬ËGimmeââ¬â¢ your lunch moneyâ⬠has turned into texting and posting gruesome threats and embarrassing material all over social media. Millions of kids all over the world have taken their own lives due to the harmful effects of cyber bullying. Problems that cannot be resolved independently are brought to court, and the government has become increasingly involvedRead MoreCyber Bullying And Its Effect On Our Youth930 Words à |à 4 PagesCyber-bulling ââ¬Å"Cyber-bullying and its Effect on our Youth,â⬠has released some useful information to American Osteopathic Association directed by unknown author and Dr. Jennifer N. Caudle, certified family physician. Dr. Caudle approaches to parents while she breaks down some statistics that could potentially prevent cyber bullying. Although, the author of the article along with Dr. Caudle does not reveal sufficient information of cyber bullying, the information given can be wisely incorporatedRead MoreCyber Bullying1493 Words à |à 6 PagesPLAYED ON MEAGAN IS KNOWN AS CYBER BULLYING. IN THE YEARS SINCE I FIRST HEARD THIS STORY Iââ¬â¢VE HEARD PLENTY MORE STORIES THAT FIT THIS CATEGORY SUCH AS THE SUICIDE OF RYAN HALLIGAN, AND TYLER CLEMENTI JUST TO NAME A COUPLE. CONSTANTLY HEARING THESE STORIES IN THE NEWS LET ME KNOW THAT CYBER-BULLYING IS A GROWING PHENOMENON AFFECTING MANY LIVES AROUND THE WORLD WHICH IS WHY I CHOSE THIS TOPIC TO RESEARCH. TODAY I WANT TO TELL YOU WHAT PROFESS IONALS DESCRIBE AS CYBER-BULLYING ,SOME OF THE ACCREDITED RESEARCHRead MoreAn Analysis of Cyber-Bullying in a Multiethnic Sample Essays974 Words à |à 4 Pagesand teachers alike in combating what is popularly known as cyber-bullying. Cyber-bullying emerged from the anonymity technology provides bullies, the victimsââ¬â¢ would receive repeated taunts, flames, in the form of emails, text messages, messages lefts on the victimsââ¬â¢ social networking sites up to exclusion from those media sites. Goebert, D., Else, I., Matsu, C., Chung-Do, J., and Chang, J.Y., (2011) looked into the effects of cyber bullying on the mental health of ethnic high school students. The
Brigham Young Free Essays
Do you know that individuals like the ââ¬ËAmerican Jesusââ¬â¢ are historically rare to find in the world? Brigham Young is a man who led many into proclaiming the ââ¬Ëgood newsââ¬â¢ of the Lord God of Israel. He led a band of men stripped of their worldly possessions into territories unknown. He had neither financial nor political backing but he was successful in establishing an industrious as well as an organized society. We will write a custom essay sample on Brigham Young or any similar topic only for you Order Now The only authority that he had was priesthood and of course his spiritual power. He gathered his people like a hen would to its chicks and gave them the sweet bread of life; the Gospel; the word of God (Arrington, L.à Nibley H. nd). Brigham Young is one of the leading historical figures as far as the Mormon Religion is concerned. His life patterns well with that of Jesus Christ of Nazareth in the Bible in his mission to spread the word of God to every corner of the World. This essay therefore looks at Brigham Youngââ¬â¢s life in relation to that of Jesus of Nazareth. Background To get a clear picture of the life patterns of Brigham, it is important to first get an insight of his background. Brigham Young was born on 1st June of the year 1801 in Whitingham in Vermont. He was the 9th born out of the eleven children that John Young with his wife Abigail Howe were blessed with. The family moved to New York when Brigham was only three years of age. He grew up helping his parents in their daily chores. His caring heart was revealed early when he took care of his ailing mother who had been suffering from tuberculosis. He was perhaps being prepared for his future role to take care of a larger flock. At the age of fourteen, his mother died and his father remarried. Brigham left from home to stay for sometime with a sister in Auburn. There he became a successful apprentice carpenter, glazier and a painter (Arrington, L. Nibley H. nd). Later in 1823 he moved to New York where he worked as a carpenter and a painter in Port Byron. At twenty three, he married Miriam Works (though he would later marry multiple wives after her death) and joined the Church of Methodist. After the birth of their first child, they moved to Oswego where he joined a religious seekers group. H e then moved his family near his father at Mendon. Joseph Smith the then leader of Mormon in his church mission passed by Mendon and left a copy of the Book of Mormons with a brother to Brigham. Brigham got access of the book and after going through it was greatly impressed. Two years later, he was baptized and became a believer of Mormon (Arrington, L. Nibley H. nd). Following in the footsteps of Jesus of Nazareth Like Jesus Christ of Nazareth, Brigham had a burning desire to make known the gospel across the world. During his first summon just one week after he was baptized, Brigham declared that after baptism ââ¬Å"I wanted to thunder and roar out the Gospel to the nations. It burned in my bones like fire pent up, so I commenced to preachâ⬠¦. Nothing would satisfy me but to cry abroad in the world, what the Lord was doing in the latter daysâ⬠Putting into practice his words, thundering and roaring of the gospel he did. Like Jesus leaving his father, Brigham left his family to go ââ¬Ëabroadââ¬â¢ and establish Godââ¬â¢s kingdom (Arrington, L. Nibley H. nd). Like Jesus, his work in the service of God started in his home town and then spread abroad. His preaching missions carried him to every corner of Mendon. His dedication as well as his potential qualified him to join the Quorum of the Twelve Apostles in the Mormon Church of Joseph Smith. The Twelveââ¬â¢s duty was to travel far and wide to spread the gospel. They preached to all nations and to people of different kinds. Their stay was not at home but away where the gospel had not reached. Afterwards, The Twelve moved to Great Britain to act as missionaries of the word of God. Brigham had left his family in dire poverty and was determined to reach England or better die in his trying to. He was ready to die Jesusââ¬â¢ way for a cause which he believed in; spread the Gospel. In Britain, Brigham out of his prowess directed all the works of The Twelve. In the same footsteps of Jesus of Nazareth, he had greatly inspired The Twelve and no wonder they made him their leader and overseer (Arrington, L. Nibley H. nd). When the Twelve Apostles came back to Nauvoo, Brigham was assigned the role of directing the apostles by Joseph Smith in their missionary work as well as other activities like land purchasing and construction projects. Playing Jesus, Brigham was now the leader of the Twelve Disciples. He was the assistant of Joseph Smith who was the First president as far as authority and responsibility was concerned. It is thus clear that he took the second position after Joseph Smith which placed him in a similar position with that of Jesus; Jesus was also the second after God. This position made him more influential to not only his disciples but also in the whole of Nauvoo and abroad in general. Even after the death of his Spiritual Father, Joseph died; he remained the leader of the Twelve until his own death in 1877. They travelled far and wide preaching the Gospel, the work that they had been called to do. Long afterwards, the work that Brigham had started continued. Before he had died, he had organized the leadership of the church of Mormon. He had lived a life by the example of Jesus Christ and fitted perfectly in the footsteps of The Son of God (Arrington, L. Nibley H. nd). Despite his good work, just like many other Mormonism men, Brigham used his status to take in plural wives. He used his missionary work as a tool to take advantage of vulnerable women. For instance, his second wife Mary was a window. Just like in Jesusââ¬â¢ time, when many, claiming to be the Son of God and savior took advantage of the poor and sinful, Brigham is not an exception of those who took advantage of the doctrine (Mormon Heteric, 2009). Was Brigham true or a False Prophet? Could Brigham have been a prophet of darkness? The words in the Bible in the book of Deuteronomy 13: 1-5 can help clear the confusion between a true and a false prophet. It says that a prophet may foretell things to happen in the future and they shall come to pass. However, a man may have miraculous powers but not actually a prophet of the Lord. Any of the prophets who encourage the worshiping of other gods apart from the God of Israel is false. Jesus himself in the gospels is quoted warning that ââ¬Å"many will come in my name, saying, ââ¬ËI am the Messiahââ¬â¢ and they will lead many astrayâ⬠according to the works of Brigham and in the limelight of these statements, does Brigham qualify as a prophet of God? (Ulachos, 1979). In history, a few poses the character of Young. For a period of thirty years, he gave himself wholly to the service of the Lord. He claimed to be a prophet in the Church of Mormon. Though he was the chair of the of the Mormon Church who presided the longest, he in fact taught false doctrine that directed its worship to a god who is not the Lord God of Israel. He had given a sermon that God and Jesus had physical bodies made of bone as well as flesh. He concluded that Adam was in fact the God of Israel who should be worshipped. The claim by Brigham that Adam was God makes it clear that he was not a true prophet of the Lord; he was false and uninspired. Because of his belief, Brigham fell out with his disciples and still many opposed him (Ulachos, 1979). More so, he put it that Jesus Christ was begotten of the father who was their God. Adam was God and therefore, Jesus was his son. Many people did not like his interpretation of the New Testament and they opposed him. However, he managed to draw a group of them to believe that Adam was their God and Jesus his son. They defended him saying that people had misunderstood Young. If he had made a mistake, he would have corrected himself which he never did. This meant that his mind was right. His preaching of his own interpretation of the gospel from what was written down in the New Testament makes him no exception of a false prophet (Ulachos, 1979). Conclusion Brigham Youngââ¬â¢s work in spreading the Gospel of the Lord God of Israel pictures well with that of Jesus Christ of Nazareth. He set out to do what many at the time could not have done and that is why to the present day, he is remembered in the Mormon Doctrine as one who made a great impact to the Church. Through the Gospel works, he rose from a humble background to a man who could sustain and give his twenty families a good life. Some of his teachings leave people wondering whether he was a true prophet of the Lord God as he claimed to be. However over the centuries, it has been an almost impossible task to identify who a false prophet is. References Arrington, L. Nibley H. (nd). Brigham Young. Retrieved from http://www. lightplanet. com/mormons/people/brigham_young. html Mormon Heteric. (2009). Economics of polygamy, divorce, and happiness. Retrieved http://www. mormonheretic. org/2009/11/15/economics-of-polygamy-divorce-and-happiness-daynes-part-4/- Ulanchos, C. (1979). Brigham Youngââ¬â¢s False Teaching: Adam is God. Retrieved http://www. beyondweird. com/occult/adam. html How to cite Brigham Young, Papers
The Significance Of Teacher Essay Sample free essay sample
The significance of the teacherââ¬â¢s personality must be emphasized in any modern society. Supervisors should hold innate abilities to react to studentsââ¬â¢ jobs sufficiently and heighten their penetration by using his/her ain cognition or experience gained antecedently. It is this uninterrupted apprehension of studentââ¬â¢s demands and ways of thought. and the capacity to place the thoughts that little kids and adolescents do desire to implement. and to guarantee aid and support to enable them to ââ¬Å"melt inâ⬠. which makes training such demanding and exciting procedure. Taking into history all the grounds indicated above it would be appropriate to observe that to go a professional pedagogue one should by nature have a set of communicational accomplishments. and leading features. Extra preparations and classs may merely heighten pedagogical ability and heighten the instruction experience. In order for the individual to form efficient learning procedure. s/he should include the undermentioned characteristics: In would be good to reason that instructors non merely have to utilize their congenital endowments. We will write a custom essay sample on The Significance Of Teacher Essay Sample or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page but besides better them by agencies of regular preparations. classs. work-shops. etc. to guarantee high-quality pedagogical procedure. Mentions Kincholoe. J. . Slattery. P. . A ; Steinberg. S. ( 2000 ) .Contextualizing instruction.New York: Longman
Friday, May 1, 2020
Discrimination against Black and Whites Essay Example For Students
Discrimination against Black and Whites Essay This story, Black Boy is a great book that describes how the author, Richard Wright, suffered in the South of the United States during the time when there was still a lot of discrimination throughout the country. Since the author explained many of his horrible experiences in the past, this book cannot be written in a thin book. This thick book is full of his great experiences that wanted to be read by many people in the world in order to let everybody know the disasters of racism. This racism affected Richard Write a lot and he had to adapt to the environment that he was in, although he didnââ¬â¢t know how he should act in front of white people in the beginning of the story. There are not many examples in the beginning of the story since Richard was a little boy, and he still didnââ¬â¢t know about racism. He did know that something was different between black and whites, but he wasnââ¬â¢t able to understand it since he was too young. He even talks to himself in Pg. 49 that ââ¬Å"I had heard that colored people were killed and beaten, but so far it all had seemed remote. There was, of course, a vague uneasiness about it all, but I would be able to handle that when I came to it. It would be simple. If anybody tried to kill me, then I would kill them first. â⬠After this, he realized the harshness of racism around his society when Uncle Hoskins got shot by a white man when he was at the saloon. And the reason is just because a black man was earning a lot of money and the white man became jealous. Also after this scene, there is an another example in Pg. 172 where he met his classmate, Ned Greenley who had lost his brother since the whites shot him for a specific reason. Ned said, ââ¬Å"Th-they said he was fooling with a white prostitute there in the hotel. â⬠Richard was shocked since he could be in those kinds of situations at any time. Richards starts to think of really going to North soon as possible now. In Chapter nine, there is a scene that is really harsh where Richard sees it, but could do nothing. This scene is at the clothing store for black people where Richard worked. The black employees were treated like slaves in the store; the white owners would push, kick, or slap the blacks. Although Richard saw this scene many times, he never got used to it. Another big thing is the time when Richard sees a black woman getting raped by two white men. This is a part from the book that describes how evil this time of period was. On Pg. 179, it says, ââ¬Å"White people passed and looked on without expression. A white policeman watched from the corner, twirling his night stick; but he made no move. I watched out of the corner of my eyes, but I never slackened the strokes of my chamois upon the brass. After a moment or two I heard shrill screams coming from the rear room of the store; later the woman stumbled out, bleeding, crying, holding her stomach, her clothing torn. When she reached the sidewalk, the policeman met her, grabbed her, accused her of being drunk, called a patrol wagon and carted her away. â⬠When I read this scene, it really hurt my heart. I couldnââ¬â¢t believe that the police didnââ¬â¢t do anything at all and although the policeman knew that the black woman was raped, he accused her of being drunken. .u25a8839c662b31baf1dd7b24edf77315 , .u25a8839c662b31baf1dd7b24edf77315 .postImageUrl , .u25a8839c662b31baf1dd7b24edf77315 .centered-text-area { min-height: 80px; position: relative; } .u25a8839c662b31baf1dd7b24edf77315 , .u25a8839c662b31baf1dd7b24edf77315:hover , .u25a8839c662b31baf1dd7b24edf77315:visited , .u25a8839c662b31baf1dd7b24edf77315:active { border:0!important; } .u25a8839c662b31baf1dd7b24edf77315 .clearfix:after { content: ""; display: table; clear: both; } .u25a8839c662b31baf1dd7b24edf77315 { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u25a8839c662b31baf1dd7b24edf77315:active , .u25a8839c662b31baf1dd7b24edf77315:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u25a8839c662b31baf1dd7b24edf77315 .centered-text-area { width: 100%; position: relative ; } .u25a8839c662b31baf1dd7b24edf77315 .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u25a8839c662b31baf1dd7b24edf77315 .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u25a8839c662b31baf1dd7b24edf77315 .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u25a8839c662b31baf1dd7b24edf77315:hover .ctaButton { background-color: #34495E!important; } .u25a8839c662b31baf1dd7b24edf77315 .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u25a8839c662b31baf1dd7b24edf77315 .u25a8839c662b31baf1dd7b24edf77315-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u25a8839c662b31baf1dd7b24edf77315:after { content: ""; display: block; clear: both; } READ: How Does Gatsby Represent The American Dream EssayRichard could have thought of saving the woman, but if he did something to the whites, he could be killed. Therefore, Richard wasnââ¬â¢t able to do anything. All he could do was to feel sorry for the lady. This doesnââ¬â¢t mean that Richard didnââ¬â¢t worry about the woman, it was the way how he had to act in the South. After Richard realizes the social cycle between the whites and the blacks at his work place, he sacrifices his morals to save more money. He begins to bootleg liquor to sell to white prostitutes in the hotel that he worked at. After that, he involves in a ring for scamming tickets. Then, he quickly amasses enough money to move out to the North. Although Richard was working earnest, he quits it because it was very hard to collect money if he had worked earnestly. Since Richard Write had an experience that he does not want to experience anymore, he was able to write this book, which would tell all the readers that discrimination or racism is not a good thing to do. He explained how he had to act as a black man; if he didnââ¬â¢t act like a black man, he might have not gotten the chance of writing this book. Richard Write had explained how blacks should act as a black, and although many horrible things were occurring around him, he wasnââ¬â¢t able to change it since he was just a black man. I feel that Richard really wanted to resist against the white men but if he did, he knew that he was going to be dead. Although in the beginning of the story, he said that, ââ¬Å"If anybody tried to kill me, then I would kill them firstâ⬠, as a result he wasnââ¬â¢t able to disobey the whites because he was scared of death. Since he was able to adapt to the society that he was in, he was able to earn money and was able to go to the North to have a better life.
Saturday, March 21, 2020
Popular College Interview Questions to Score Your Admission
The 10 College Interview Questions To Prepare For As youââ¬â¢re applying for college, thereââ¬â¢s a chance to leave a good impression and show the admission committee that you will add value to the institution. Giving unique and impressive answers to college interview questions will interest the person interviewing you, so they will talk to you, ask about your dreams, and discuss how you plan on achieving them. Colleges encourage students to talk with an admission representative so they can ask questions related to college-life as well as express themselves and discuss their ambitions. These representatives will consider these answers when theyââ¬â¢re reading the rest of studentsââ¬â¢ admission papers. The 10 Most Typical College Interview Questions As youââ¬â¢re getting ready for your college admission phase, you must be well-prepared. Every minute you spend preparing will provide you with data and information that make the job a lot easier. Admission for college and university is very competitive because there are hundreds of students competing for the same seat and opportunity. Prove that youââ¬â¢re special and have what it takes to succeed as a college student. In addition to learning how to write a good college application essay, you should revise some college interview questions to have impressive answers ready. Here are some typical college admission interview questions that most students hear when theyââ¬â¢re applying for a university or college. Why did you choose this college or university? This classical question is one of the most common ones that students are likely to hear. The answer should involve some referral to the programs offered by the institution. Do they offer a special drama program? Are you interested in their baseball team? The answer should make sense. Who are you? In a college interview, the representative wants to know who you really are. Avoid clichà ©s and make sure you refer to past experiences. Why this major? While you might not have explained this in your application personal statement, you can talk about your academic goals in the interview. Talk about academic topics that interest you and how you plan on using this major to reach your professional goals. Where do you want to be in 10 years? Grad school interview questions show how ambitious you are. An interviewer will ask about how you view your future and where youââ¬â¢ll be in 10 years. Discuss a plan and not just wishes that arenââ¬â¢t based on hard work. Talk about an experience that left a great impact on you. We normally experience growth as the years go by. Talk about a special experience that changed your views about the world. It can be a movie, a book, or an encounter with a special person that left a great impression on your life. What academic strength do you have? Use a unique story to support your claims. Donââ¬â¢t say that youââ¬â¢re smart or hardworking. Make sure not to brag because you should be honest. What activities are you interested in? As youââ¬â¢re studying how to prep for an interview, you shouldnââ¬â¢t ignore extracurricular activities. College and university life isnââ¬â¢t just about studying lessons. Itââ¬â¢s a full social experience that will have an impact on your future as an adult. Donââ¬â¢t worry if you think that youââ¬â¢re not interested in the most popular activities. Show the committee representative that youââ¬â¢re a unique person with special features. What weaknesses did you face at school, and how did you overcome them? Again, honesty is appreciated, but consider keeping some information to yourself. You donââ¬â¢t have to tell the representative that youââ¬â¢ve used an admission essays guide to write the college admission essay, right? Whoââ¬â¢s your role model in real life? Try to choose someone you know on a personal level, rather than a famous historical figure. Itââ¬â¢s easier to relate to that personââ¬â¢s life and explain why and how it affected yours. Do you have any questions? Asking questions shows that youââ¬â¢ve done enough research about the college or university. Take this opportunity and discuss any important questions like the most critical tips new students should know. College Interview Questions From Top Universities Every college or university has a set of questions that the admission committee usually asks. Harvard: They will probably ask you why you want to study at Harvard. Then after a few general questions, students are usually asked a tricky question. For example, one about the most negative experience they faced at school. UPenn: The first question is usually, ââ¬Å"Can you tell me a little about yourself?â⬠This is an ice-breaker and is usually followed by more challenging ones. Columbia: The representative usually asks students about their short and long-term goals. Students should elaborate and share their passion. Yale: As one of the most famous schools, Yale representatives pursue the most special students to join their institution. They will ask what you do for fun, and why did you stick to a certain interest. MIT: There is no right or wrong answer here. The representative will probably ask about the challenges you think are unique to MIT students. Boston College: Youââ¬â¢ll be asked about the most and least courses you loved in school. You can also talk about an achievement that made you feel extremely satisfied. Princeton: Students will be asked about what they like to do when theyââ¬â¢re not in class. The representative will also ask about a mistake and how you learned from it. How To Prepare For A College Interview? The time you spend preparing for college interview isnââ¬â¢t wasted. Youââ¬â¢re getting ready for the most important phase of your life and every word you say should count. Your interviewer expects a few questions that show that youââ¬â¢re really interested. Practice answering the most common questions with a friend or an ex-graduate so you can be ready with impressive answers. What To Wear To A College Interview? Most young people feel confused about the right college interview outfit. It should be simple yet elegant without attracting too much attention. For men, business casual attire works perfectly. This means that they should wear long-sleeved shirts with dress pants or khakis. They can also wear a jacket and tie. If the interviewer states that itââ¬â¢s casual, you can wear your tailored jeans, but nothing ripped or too edgy. For women, tailored suits work well. If youââ¬â¢re wearing a dress, it should have sleeves or you can top it with a blazer. The skirt shouldnââ¬â¢t be too short or tight. Avoid wearing flip flops and sandals. What To Bring To A College Interview? Do you have a document that shows some of your accomplishments? An award? Bring these in addition to two copies of your resume for the interview. Bring a notebook and a pen to take notes when necessary. Sometimes, the college will provide students with a list of things they should bring to the interview like a list of the AP exams youââ¬â¢ve taken or plan to take, a previous portfolio of artwork and designs, or a performance video. Hold all of these items in a neat bag. College Interview Tips Thereââ¬â¢s no need to panic as youââ¬â¢re getting ready for the interview. This is your chance to realize your potential, and you should be happy to grab it. Arrive ahead of time. Itââ¬â¢s better to be early than late. Enjoy the conversation. Donââ¬â¢t try to memorize some questions and answers as this leaves a bad impression. Keep some information to yourself. Itââ¬â¢s not wise to tell the representative that youââ¬â¢ve hired a write my college application essay service to finish your assignment. Be yourself. No one is judging you. Practice with friends and family. How To Answer Unexpected Questions? Did your interviewer throw an unexpected question at your way? Donââ¬â¢t panic. Hereââ¬â¢s what you should do if youââ¬â¢re not given one of the common college interview questions. Calm down to give yourself a chance to think about a good answer. Ask questions for more clarification. Ask the interviewer to rephrase. Tell your interviewer something that you actually know. Itââ¬â¢s OK if you donââ¬â¢t have all the answers. Students join college or university to learn more about academic topics and life. Are you nervous about your college interview? Practicing several questions will make the job easier. Your interviewerââ¬â¢s aim isnââ¬â¢t to fail you or deprive you of your dreams, but they want to learn more about you. Be yourself, and donââ¬â¢t hesitate to speak up!
Thursday, March 5, 2020
Multiple Points of Exclamation!!!
Multiple Points of Exclamation!!! Multiple Points of Exclamation!!! Multiple Points of Exclamation!!! By Michael If you want to strongly emphasize a sentence, either because its emphatic or humorous, you may sparingly use a exclamation point. But use it sparingly! Its supposed to express strong emotion. Dont use more than one at the end of a sentence, unless youre a strongly-emotional fourteen-year-old girl writing on MySpace. Much better: use exclamation points no more than once per page. Like the boy who cried Wolf so often that nobody believed him when he saw a real wolf, you dont want to become known as the writer who cried Exclamation when there wasnt really anything worth exclaiming about. If the exclamation is part of a quotation, put the exclamation point inside the quotes. So, if it represents your strong emotion, put the exclamation point outside the quotation marks. If youre quoting someone else with strong emotions, put the exclamation point inside the quotes. For example: I cant believe that you used multiple exclamation points when you wrote, Whatever!!, especially at your age, Grandmother! The same can be said about interrogation marks. One is enough, even if you are really curious about what you are asking. Maeve Maddox once wrote a post here recommending writers to let the word do the work. Well, they should also let the punctuation mark do the work! No multiple exclamation or interrogation marks, please. Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Punctuation category, check our popular posts, or choose a related post below:Inquire vs EnquireOne Fell Swoop30 Words Invented by Shakespeare
Monday, February 17, 2020
3.Can terrorism be risk managed Discuss with reference to old and new Essay
3.Can terrorism be risk managed Discuss with reference to old and new forms of terrorism - Essay Example To actualize this threat, they may decide to harm one who opposes their candidate. The fact is that voting is secret and the bully knows that to increase the chances of his candidate winning, he has to ensure that there is increased pressure and more harm. This is how terrorism activity occurs (Samuels, 2008). To begin the essay, there are many other forms of evil deeds that are often confused with terrorism. These include murder, assassination, assault, battery, destruction of property, theft, robbery, rape, extortion and espionage. All these are not terrorism, but can be utilized by terrorists to conduct terrorism (Melisow, 2008). In these modern times, terrorism is used for political gains. Politics is not an individual game; rather, it involves a group. Most of these political activities are controlled by governments. This forms a soft target by the terrorists, who want to affect government activities and change the way a government performs by scaring people in a country (Melisow, 2008). This sentiment is echoed by Hoffman who states that terrorism is all about power; itââ¬â¢s the pursuit of power, its acquisition, and subsequent use for political change (2013). The old terrorism was practiced during the French revolution. Despite its modern-day use, it had a positive implication. It occurred during the period of 1793-1794 during the transient anarchical period of unrest, as a result of the 1789 uprising (Hoffman, 2013). Although the current world refers to it as terrorism, during the earlier times, it was known as an instrument used by the government of a new revolutionary state. Hoffman points out that ââ¬Å"it was designed to consolidate the new governmentââ¬â¢s power by intimidating counter revolutionariesâ⬠(2013, p.3). It constituted the committee of general security and revolutionary tribunal. They were very powerful and had the ability to arrest and prosecute by form of death, anyone who tried to oppose the revolution. The earlier
Monday, February 3, 2020
Session Planning Essay Example | Topics and Well Written Essays - 500 words
Session Planning - Essay Example However, these requirements are different for Bass players. They will play directly from our solid-state pre amps and direct boxes for direct recording. Please be advised to use strings in your guitar and donââ¬â¢t forget to tune them a several times before the session for the correct pitch. For keyboardists, please note to bring your own keyboards and its stand. You are required to bring your own power cables, pedals and manuals. Although, we have different MIDI gear and other devices available at the studio but we would advise you to use your own for better sound quality. Similarly, Drummers need to bring their own drums to the studio on the day of session. Before final recordings make sure the heads are newly installed along with pedals that do not squeak at all. Drums should be finely tuned before the session. For vocalist, please rehearse again and again to know the notes and lyrics by heart. Make sure you know all the highs and lows of the notes required in your song. Musicians required will be: One drummer, one keyboardist, two bass guitarists, one on electric guitars, a vocalist with three background supporting vocalists and other musicians if required any by the band. The setting of the musicians is set apart so their mics will not interfere with each other. We have made sure that there should be enough distance between vocalist and the drummer and between the guitarists and the keyboardists. There are 9 tracks to be played in the session. 5 out of 9 tracks will be recorded on acoustic guitars whereas; the remaining 4 songs will be pop/country. They would be the unplugged low versions. Each day each song will be given approximately 5-6 minutes during the entire session including the rehearsals. The people apart from the musicians will consist of our technical team, studio engineer, sound engineer and the management. Please avoid bringing any
Sunday, January 26, 2020
The Use of Mixl1 in Ex Vivo and Chimeric Organ Regeneration
The Use of Mixl1 in Ex Vivo and Chimeric Organ Regeneration Anokhi Kashiparekh à TA: Goheun Kim Regenerative medicine is a field in biology that uses the underlying cell properties of differentiated growth to create entire tissues and organs from that cell. Regeneration in its true form, applies human pluripotent stem cell (hPSCs) differentiation, to make new organs like the natural regeneration of the human liver or that of the zebrafish heart (Mostoway et al, 2013). A very useful area for such a technique is the organ donation and replacement discipline. One of the greatest challenges for organ replacement is the shortage of organs donated for the cause. This is where the field of regenerative medicine can come in use. If the cells of the person in need of the organs can differentiate in a way that fills up the niche left by the diseased or missing organ, there could be a remarkable decrease in the need for organ transplantation and organ rejection. However, the development of the human organs is a gradual process and may take longer than the time the patient has to survive. A tactic to increase the speediness and the efficiency of organ regeneration is to manipulate certain genes to promote either ex vivo differentiation or differentiation in a chimeric host with a faster developmental time than humans. Specific genes can be engineered to perform specific functions, like prompting apoptosis using the Bcl-2 gene or assessing mesodermal markers using Wnt3 (Wu et al, 2016). Inducing Mixl1, the endoderm and mesoderm formation transcription factor, can play an important role in generating organs from induced pluripotent stem cells (iPSCs). Mixl1 plays an important role in chimeric and ex vivo regeneration models; although further research is required on the viability of these models. The Mixl1 transcription factor binds to the Mix gene and is a part of the hox gene family that codes for homeodomain proteins. The most important function of the Mixl1 is the regulation of cell fate and differentiation during the developmental stages of an organisms life. It regulates the formation of the endodermal and mesodermal layers and consequently can be used to manipulate hPSCs towards a particular lineage of growth. This principal property of the Mixl1 gene, as well its interactions with other genes, has been the focus of genetic regenerative medicine, in order to understand the role and consequent use of said genes. Various experiments have tried to incorporate the Mixl1 system in stem cell growth but two of the most widely known models are the ex vivo regeneration model and the chimeric model. Both of these models rely on the property of Mixl1 to guide iPSCs towards either endodermal or mesodermal fate. The basic difference between these models is the environment in which these cells are allowed to differentiate. The ex vivo model allows cell differentiation and growth outside an organism, generally in a laboratory. It is a widely preferred model due to the fact that cells from an organism can be extracted, cultured in a lab and placed back in the same organism. Each step in the experiment can be tracked and monitored and all the cells are cultured in a sterile environment. Thus, the cells placed back inside the animal are safe from potential bacteria or viruses. However, this also means that the organs generated from this may not be compatible with the surrounding tissue when introduced in an organisms body, due to the lack of interaction with other cells. Ex vivo culture of cells and ultimate organ regeneration is a step towards solving the problem of limited availability of desired cells. This ex vivo model of organ regeneration makes use of different substrates to recreate a natural differentiating environment for the cultured cells. However most times it is hard to push the hPSCs towards a particular lineage of growth, i.e. mesodermal or endodermal. The Mixl1 gene with its property to establish cell fate, is useful in resolving this. The forced expression of Mixl1 in hPSCs, in the right environment, with particular substrates and specific protein mediums, can promote ex vivo cell differentiation. Ex vivo culture, with connection to the Mixl1 gene is efficient due to the control over time of forced expression of the Mixl1 gene as well as external monitoring of the growth. Liu et al (2011)3 established this by using Là °Ã à à °5ÃŽà ²1 and Là °Ã à à °6ÃŽà ²1 protein ligands to promote Mixl1 induced hPSCs, in a BMP4 medium. The procedure included purifying polypeptides, culturing the hPSCs and allowing them to differentiate. The results showed that the differentiation of cells peaked on the third (to) fourth day of culture when both the LÃŽà ±5ÃŽà ²1 and Là °Ã à à °6ÃŽà ²1 protein ligands were used. This gradual growth was tracked using immunofluorescence and analyzed by flow cytometry. The results of this experiment encompass both the usefulness as well as the disadvantages of an ex vivo regeneration of organs using Mixl1. The biggest challenge encountered in an ex vivo organ regeneration model is the limited number of substrates that the hPSCs can use and differentiate into a mesodermal lineage. In various cases, Mixl1 is induced unsuccessfully. This is due to the high substance substrate specificity of the iPSCs that do not survive long enough for Mixl1 to express and differentiate. Another case seen in Liu et al was the very minute expression of Mixl1 when cultured with various other individual ligands, showing that this procedure also requires the correct combination of substrates. Various agencies have also raised ethical concerns over culturing animal cells in labs. The obtaining of cells, external media and substrates from animal bodies is cited as animal abuse (cruelty). To minimize the use of animal products, a more specific area of the ex vivo model has been developed, called the xeno-free culture. Typically, all components required for a xeno-free culture come from the same organism while taking care that it is completely free of animal or human elements, like bovine blood for culturing media, etc. As a replacement to these essential components, researchers are trying to synthesize new protein ligands that can function in a similar pattern4. To reiterate, genetic manipulation of the ex vivo model has the potential to save lives but requires a deeper study in the areas of limited substrate compatibility and availability. In contrast to the ex vivo model, the chimeric model revolves around cell differentiation inside a living body. Chimeras are organisms made up of a combination of two or more zygotes and thus this model introduces extraction from and cell differentiation in two different individuals. Generation of embryonic chimeras is of both practical and conceptual importance as it provides a method to assess the developmental competence of cells. The cells of the different individuals on the same embryo can be tracked and genes can be manipulated to create a chimeric organism that can act as a vessel for organ generation. Blastocyst complementation and target organ complementation are two important techniques in chimeric organ regeneration. While blastocyst complementation uses iPSCs transferred to an embryo of another species, generally a porcine embryo, target organ complementation is focused on the regeneration of specific organs of the body. Due to the unconventionality, the adherence to soci al and ethical limitations is of great importance and requires more research to be conducted. Experiments combining this regenerative model and the forced expression of the Mixl1 gene have been successful in producing organs in different hosts. By trying to reconcile the idea of targeted generation of organs derived by using the patients own PSCs as seen in the case of the mice, Kobayashi et al (2016) makes use of blastocyst complementation to create pancreatogenesisor nephrogenesis-disabled mice. Blastocyst complementation is a technique that makes use of induced human pluripotent stem cells (iPSCs) transferred to an embryo of another species; thus, following cell growth in another body. This study used Pdx1-LacZ heterozygous mice as the chimeric hosts and injected humanized pancreatic cells in the blastocyst. This complementation was followed by the forced induction and expression of the Mixl1 gene using the pRosa26-tTA-Mixl1 vector. The data was analyzed by Western blotting and flow cytometry. The immediate result showed chimeric cells throughout the bodies of the mice. The mice were then introduced to a cell medium without Doxycycline (Dox). Immunofluorescence confirmed the distribution of cells being confined to just the guts, showing that specific target organ regeneration is possible with suitable environmental conditions and resources for the culturing cells. The forced expression of the MIxl1 gene represses mesodermal fate determination and promotes endodermal fate determination, thus helping to induce the formation of target specific organs, including the pancreas or the liver, in the disabled mice. In order to test for the amount of time Mixl1 takes to express, these mice were injected with Dox at various time intervals and the results were examined using EpCAM, an endodermal genetic marker. The cell growth apex was noted on the 4t h day of Dox administration. This leads to the belief that time is an important factor in understanding cell growth in chimeric organisms. To understand the regulation of Mixl1 based on biological functions, it was allowed to express under the influence of Oct3/4, a genetic marker seen to express in early development. The absence and presence of Dox in the host chimera was compared to establish that its absence would achieve specific target organ regeneration as compared to cell growth throughout the body. The data implied that Mixl1 presence was necessary until the epiblast stage. This gives way to the inference that the time taken for Mixl1 to express can be reduced, thus giving way to a quicker technique of organ regeneration. This model, although promising, is questionable due to the ethical controversies like the formation of human neural cells or germ cells in the host animal. This is a cause for concern due to the fact that the idea of a human brain trapped inside a mute animal is disturbing. Proper manipulation of cell differentiating genes like Mixl1 is essential to keep hPSCs from turning into cells that could humanize the host animal. While understanding and experimenting on techniques that help in human advancement, there has to be a larger focus on the social and ethical concerns of utilizing them. In conclusion, although it is limited by growing ethical concerns, genetic manipulation in chimera may help save lives with the advancement in understanding cell repair and regeneration. Thus, the idea of organ regeneration using chimerism should be looked into by science but in a way that can appeal to social principles. Another problem associated with this model of regeneration is the low success rate of differentiation in non- rodent animals2. Majority chimera experiments include rodent species as the main focus, due to both the size and relatively easy manipulation of the rodents. Although recent experiments have shown (that) porcine hosts act as good carriers for human pancreatic growth6, there is a lot of research to establish pigs as conventional hPSC hosts in order to continue chimeric research to generate bigger organs like the human heart or the human lungs. While comparing the advantages and the disadvantages of both these techniques of organ regeneration, the role and function of Mixl1 itself cannot be overlooked. Mixl1 has been shown to express within 4 days of being induced. More research may lead to a quicker expression time. Mixl1 has also helped to achieve a target specific organ regeneration by promoting mesodermal differentiation as required. The use of Mixl1 is enormous in the field of regenerative biology and can be used in other projects as well as models of regeneration. In conclusion, both ex vivo regeneration and chimeric regeneration have flaws but it is possible to refine them for better and more specific results. While the usefulness of Mixl1 cannot be denied, better models of regeneration must be established to achieve maximum efficiency for its expression. References: Mostowy, S., Boucontet, L., Moya, M. J. M., Sirianni, A., Boudinot, P., Hollinshead, M., Colucci-Guyon, E. (2013). The zebrafish as a new model for the in vivo study of Shigella flexneri interaction with phagocytes and bacterial autophagy. PLoS Pathogens, 9(9) Wu, J., Greely, H. T., Jaenisch, R., Nakauchi, H., Rossant, J., Juan Carlos Izpisua Belmonte. (2016). Stem cells and interspecies chimaeras. Nature, 540(7631), 51-59. Yang, L., Wang, X., Kaufman, D., Shen W. (2011) A synthetic substrate to support early mesodermal differentiation of human embryonic stem cells. Biomaterials. 2011 Nov;32(32):8058-66. Karnieli O., Friedner O., Allickson J., Zhang N., Jung S., Fiorentini D., Abraham E., Eaker S., Yong T., Chan A., Griffiths S., When A., Oh S.A consensus introduction to serum replacements and serum-free media for cellular therapies. Cytotherapy , Volume 19 , Issue 2 , 155 169. Kobayashi, T., Kato-Itoh, M., Nakauchi, H. (2015). Targeted organ generation using Mixl1-inducible mouse pluripotent stem cells in blastocyst complementation. Stem Cells and Development, 24(2), 182. Matsunari, H., Nagashima, H., Watanabe, M., Umeyama, K., Nakano, K., Nagaya, M., . . . Nakauchi, H. (2013). Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs. Proceedings of the National Academy of Sciences of the United States of America, 110(12), 4557-4562.
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